https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48090 Wed 28 Jun 2023 18:56:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45212 Wed 26 Oct 2022 15:56:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11542 Wed 11 Apr 2018 15:09:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12729 Wed 11 Apr 2018 15:05:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11541 Wed 11 Apr 2018 13:32:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29981 0.05). Overlap (P<0.0001) of differentially expressed genes in Hfe -/- × Tfr2 mut brain with human gene co-expression networks suggests iron loading influences expression of NBIA-related and myelin-related genes co-expressed in normal human basal ganglia. There was overlap (P<0.0001) of genes differentially expressed in Hfe -/- × Tfr2 mut brain and post-mortem NBIA basal ganglia. Hfe -/- × Tfr2 mut mice were hyperactive (P<0.0112) without apparent cognitive impairment by IntelliCage testing (P>0.05). These results implicate myelin-related systems involved in NBIA neuropathogenesis in early responses to iron loading. This may contribute to behavioral symptoms in NBIA and hemochromatosis and is relevant to patients with abnormal iron status and psychiatric disorders involving myelin abnormalities or resistant to conventional treatments.]]> Wed 11 Apr 2018 13:26:01 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16739 Wed 11 Apr 2018 13:23:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30004 Wed 11 Apr 2018 12:27:04 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30612 18F-Florbetaben, was employed to categorise participants as low NAL (standard uptake value ratio; SUVR < 1.35, N = 65) and high NAL or preclinical AD (SUVR ≥ 1.35, N = 35) wherein, linear models were employed to compare FA compositions between the two groups. Increased arachidonic acid (AA, p < 0.05) and decreased docosapentaenoic acid (DPA, p < 0.05) were observed in high NAL. To differentiate low from high NAL, the area under the curve (AUC) generated from a ‘base model’ comprising age, gender, APOEε4 and education (AUC = 0.794) was outperformed by base model + AA:DPA (AUC = 0.836). Our findings suggest that specific alterations in erythrocyte FA composition occur very early in the disease pathogenic trajectory, prior to cognitive impairment. As erythrocyte FA levels are reflective of tissue FA, these alterations may provide insight into the pathogenic mechanism(s) of the disease and may highlight potential early diagnostic markers and therapeutic targets.]]> Wed 11 Apr 2018 11:27:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:524 Wed 11 Apr 2018 10:44:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30417 Wed 11 Apr 2018 10:16:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30261 Wed 11 Apr 2018 10:01:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35136 Wed 10 Nov 2021 15:04:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35038 Wed 07 Jul 2021 12:04:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25973 Wed 04 Sep 2019 10:40:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40862 p = 0.003) and ED presentations (p = 0.021) at 3 months. Within the at-risk subgroup of mild cognitively impaired, the HOME intervention significantly reduced unplanned hospitalizations (p = 0.027), but the effect did not reach significance in ED visits. While the effect of HOME differed according to support received from family for participation in life roles (p = 0.019), the participation observed in HOME patients with no support was not significantly improved. Conclusions: Findings show that hospitalized older adults with mild cognitive impairment benefit from the HOME intervention, which involves preparation and post-discharge support in the environment, to reduce unplanned re-hospitalizations. Improved discharge outcomes in this at-risk subgroup following an occupational therapist-led intervention may enable best care delivery as patients transition from hospital to home.]]> Tue 19 Jul 2022 14:03:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50321 Tue 18 Jul 2023 15:05:24 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43876 Tue 04 Oct 2022 12:35:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33249 Thu 20 Sep 2018 11:30:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52643 Thu 19 Oct 2023 15:18:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43323 Thu 15 Sep 2022 14:43:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38016 Thu 14 Mar 2024 09:06:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42951 KCNJ2 gene involved in the transduction of sour taste have been linked to variations in sour taste and non-gustatory functions. However, relationships between sour taste genetics, mild cognitive impairment, and diet quality are yet to be elucidated. This study investigated the associations between the presence of the KCNJ2-rs236514 variant (A) allele, diet quality indices, and mild cognitive impairment evaluated by the Mini-Mental State Examination (MMSE), in a secondary cross-sectional analysis of data from the Retirement Health & Lifestyle Study. Data from 524 elderly Australians (≥65y) were analyzed, using standard least squares regression and nominal logistic regression modeling, with demographic adjustments applied. Results showed that the presence of the KCNJ2-A allele is associated with increased proportions of participants scoring in the range indicative of mild or more severe cognitive impairment (MMSE score of ≤26) in the total cohort, and males. These associations remained statistically significant after adjusting for age, sex, and diet quality indices. The absence of association between the KCNJ2-A allele and cognitive impairment in women may be related to their higher diet quality scores in all indices. The potential link between sour taste genotype and cognitive impairment scores may be due to both oral and extra-oral functions of sour taste receptors. Further studies are required on the role and relationship of neurotransmitters, sour taste genotypes and sour taste receptors in the brain, and dietary implications, to identify potential risk groups or avenues for therapeutic or prophylactic interventions.]]> Thu 08 Sep 2022 14:04:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38032 Thu 05 Aug 2021 10:35:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31272 Sat 24 Mar 2018 08:44:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10441 Sat 24 Mar 2018 08:13:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12278 Sat 24 Mar 2018 08:10:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26307 Sat 24 Mar 2018 07:40:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3341 Sat 24 Mar 2018 07:22:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53925 85 years and those with two or more admissions had greater odds of having CI screening documented. Among patients without CI screening documented, 72% (n = 78) were identified as cognitively impaired. While healthcare providers agreed CI screening was beneficial, they identified lack of time and poor knowledge as barriers to undertaking screening. Conclusions: CI is frequently unrecognised in the hospital setting which is a missed opportunity for the provision of appropriate care. Future research should identify feasible and effective strategies to increase implementation of CI screening in hospitals.]]> Mon 22 Jan 2024 16:41:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46264 Mon 14 Nov 2022 14:18:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40206 Mon 08 Aug 2022 13:40:29 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45466 n = 114 participants with completed cognitive outcomes at follow up were included in this analysis. Using the Cogstate Brief Battery, the following cognitive outcomes were assessed: psychomotor function, attention, visual learning and memory (visual and working). Subgroup analyses investigated whether baseline clinical parameters (baseline cognitive functioning, illness severity and duration, depressive symptoms) moderated the relationship between mangosteen pericarp extract intervention and change in cognitive outcomes. Results: There were no significant between-group changes in any cognitive outcomes assessed. Subgroup analysis based on baseline cognition and clinical characteristics did not reveal any significant between-group difference in change. Conclusions: Mangosteen pericarp extract did not affect cognitive outcomes in people with schizophrenia. Further investigation regarding optimal dosing strategies for mangosteen interventions and the testing of additional cognitive domains may be warranted.]]> Fri 28 Oct 2022 14:45:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38827 p < 0.047), whereas the measure of executive functioning was uniquely accounted for by the presence of hypertension and angina (all p < 0.032). Increased stroke risk also predicted performance on the cognitive screening test and the measure of executive functioning (all p < 0.002). Conclusions: Our findings indicate that cognitive impairment following a minor stroke or TIA may be attributed to the high prevalence of chronic vascular risk factors in these patients. This highlights the importance of long-term management of vascular risk factors beyond event recovery to reduce the risk of cognitive impairment. Increased stroke risk (i.e., ABCD2 score) was also associated with reduced cognition, suggesting that it may be helpful in signaling the need for further cognitive evaluation and intervention post-event.]]> Fri 20 May 2022 12:40:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36927 Fri 17 Jul 2020 08:58:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52975 Fri 03 Nov 2023 15:30:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24438 Fri 03 Dec 2021 10:35:17 AEDT ]]>